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Transgene Detail
Symbol: Tg(CD2-Zbtb7b)C8Rbo
Name: transgene insertion C8, Remy Bosselut
MGI ID: MGI:3817775
Synonyms: cKrox, ThPOK
Transgene: Tg(CD2-Zbtb7b)C8Rbo  Location: unknown  
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(CD2-Zbtb7b)C8Rbo expresses 1 gene
Mutation detailsCoding sequence for the Zbtb7b gene was placed under control of the human CD2 promoter and locus control region. This promoter drives expression in double-postive and single-positive thymocytes and in mature T cells. Three lines (C8, L4, L8) displaying similar phenotypes were established with the C8 line being chosen for further analysis. Transgene expression was confirmed in thymocytes by immunoprecipitation and immunoblotting. (J:97610)
View phenotypes and curated references for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:97610 Sun G, et al., The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection. Nat Immunol. 2005 Apr;6(4):373-81
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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