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Zbtb7btm3Itan
Targeted Allele Detail
Nomenclature
Symbol: Zbtb7btm3Itan
Name: zinc finger and BTB domain containing 7B; targeted mutation 3, Ichiro Taniuchi
MGI ID: MGI:3817542
Synonyms: ThPokFH
Gene: Zbtb7b  Location: Chr3:89377644-89393673 bp, - strand  Genetic Position: Chr3, 39.09 cM, cytoband A1-A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:141142
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced by a modified version of exon 1 that encoded a "Flag-HA" epitope tag at the amino terminus of the gene product. A floxed neomycin cassette was also placed downstream of the exon. After targeting, the neo-cassette was removed by transient expression of cre recombinase. Protein expression was confirmed by immunoblot assays using anti-HA antibody. (J:141142)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zbtb7b Mutation:  19 strains or lines available
References
Original:  J:141142 Muroi S, et al., Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate. Nat Immunol. 2008 Oct;9(10):1113-21
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/07/2020
MGI 6.14
The Jackson Laboratory