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Isl1tm2Sev
Targeted Allele Detail
Nomenclature
Symbol: Isl1tm2Sev
Name: ISL1 transcription factor, LIM/homeodomain; targeted mutation 2, Sylvia M Evans
MGI ID: MGI:3817457
Synonyms: Isl1f
Gene: Isl1  Location: Chr13:116298281-116309689 bp, - strand  Genetic Position: Chr13, 64.87 cM, cytoband D2.3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:141110
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 4, which encodes the homeodomain of the protein product, was floxed by the insertion of a loxP site on one end and a loxP site and frt-flanked neo cassette on the other end. After germline integration, the frt-flanked neo cassette was removed from Isl1tm4Sev by crossing with FLPe transgenic strain. (J:141110)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Isl1 Mutation:  19 strains or lines available
References
Original:  J:141110 Sun Y, et al., A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs. Nat Neurosci. 2008 Nov;11(11):1283-93
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory