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Stx1atm1Gwz
Targeted Allele Detail
Nomenclature
Symbol: Stx1atm1Gwz
Name: syntaxin 1A (brain); targeted mutation 1, Gerald W Zamponi
MGI ID: MGI:3817409
Gene: Stx1a  Location: Chr5:135023482-135051100 bp, + strand  Genetic Position: Chr5, 74.95 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:141037
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3 to 6 were replaced with a neomycin selection cassette. In addition, a stop codon was inserted in exon 2. RT-PCR of RNA extracted from the brains of homozygous mice demonstrated that no transcription occurred. (J:141037)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stx1a Mutation:  17 strains or lines available
References
Original:  J:141037 McRory JE, et al., Syntaxin 1A is required for normal in utero development. Biochem Biophys Res Commun. 2008 Oct 24;375(3):372-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory