Tg(Nes-cre/ERT2)4Kag
Transgene Detail

Summary

• Symbol: Tg(Nes-cre/ERT2)4Kag
• Name: transgene insertion 4, Ryoichiro Kageyama
• MGI ID: MGI:3817325
• Synonyms: Nes-CreER^T2, Nestin-CreER^T2line4
• Transgene: Tg(Nes-cre/ERT2)4Kag Location: unknown
• Alliance: Tg(Nes-cre/ERT2)4Kag page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Nes-cre/ERT2)4Kag expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Nes (25491)

  Nes	(MGI:101784)

• Mutation details: This transgene consists of a 5.8 kb fragment of the rat Nes promoter and a 1.8 kb fragment of the second intron of Nes driving expression of a tamoxifen-inducible form of cre recombinase followed by an SV40 poly A sequence. Three lines were created (lines 1, 4, and 5-1) with differing levels of activity (high, medium, and low, respectively) and leakiness (high, low and none, respectively). (J:110145)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nes (rat) Summary of all recombinase alleles driven by Nes. Comparative matrix view of recombinase activities Alliance rat Nes gene page

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:110145 Imayoshi I, et al., Temporal regulation of Cre recombinase activity in neural stem cells. Genesis. 2006 May;44(5):233-8
• All: 24 reference(s)