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Targeted Allele Detail
Symbol: Pcnatm1.1Mdsc
Name: proliferating cell nuclear antigen; targeted mutation 1.1, Matthew D Scharff
MGI ID: MGI:3817295
Gene: Pcna  Location: Chr2:132249286-132253180 bp, - strand  Genetic Position: Chr2, 64.15 cM
Germline Transmission:  Earliest citation of germline transmission: J:141098
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP-site was inserted upstream of exon 2 and a floxed hygromycin cassette was placed downstream of exon 4. Chimeric mice were mated to a cre recombinase transgenic strain to delete exons 2-4. Genomic PCR confirmed that the correct targeting of the vector and subsequent exon excision took place. (J:141098)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pcna Mutation:  7 strains or lines available
Original:  J:141098 Roa S, et al., Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16248-53
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory