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Edil3tm1Tq
Targeted Allele Detail
Nomenclature
Symbol: Edil3tm1Tq
Name: EGF-like repeats and discoidin I-like domains 3; targeted mutation 1, Thomas Quertermous
MGI ID: MGI:3817261
Synonyms: Del-1-
Gene: Edil3  Location: Chr13:88821472-89323223 bp, + strand  Genetic Position: Chr13, 45.3 cM, cytoband C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:141063
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe first ATG in the exon 1 was inactivated by insertion of a LacZ-Neomycin cassette at the PstI site. LacZ expression was detected in the cranium, brain, vertebral ganglia, gut, and cardiac cushions of E9.5-E11.5 embryos. Endogenous gene inactivation was confirmed by a lack of signal on Northern blots of RNA extracts from brain and lung of homozygote mice. (J:141063)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Edil3 Mutation:  6 strains or lines available
References
Original:  J:141063 Choi EY, et al., Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment. Science. 2008 Nov 14;322(5904):1101-4
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory