Cbfa2t3^tm1Swh
Targeted Allele Detail

Summary

• Symbol: Cbfa2t3^tm1Swh
• Name: CBFA2/RUNX1 translocation partner 3; targeted mutation 1, Scott W Hiebert
• MGI ID: MGI:3815200
• Synonyms: Mtg16^fl
• Gene: Cbfa2t3 Location: Chr8:123351880-123425848 bp, - strand Genetic Position: Chr8, 71.93 cM, cytoband E1
• Alliance: Cbfa2t3^tm1Swh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140967
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin cassette was placed upstream of exon 8 and an additional loxP site was placed downstream of exon 8. Genomic PCR confirmed correct targeting of the floxed allele. (J:140967)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cbfa2t3 Mutation: 34 strains or lines available

References

• Original: J:140967 Chyla BJ, et al., Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation. Mol Cell Biol. 2008 Oct;28(20):6234-47
• All: 1 reference(s)