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Nr1i3tm1(NR1I3)Arte
Targeted Allele Detail
Nomenclature
Symbol: Nr1i3tm1(NR1I3)Arte
Name: nuclear receptor subfamily 1, group I, member 3; targeted mutation 1, TaconicArtemis
MGI ID: MGI:3815103
Synonyms: huCAR
Gene: Nr1i3  Location: Chr1:171041503-171046414 bp, + strand  Genetic Position: Chr1, 79.21 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140975
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 through 9 were replaced with the human gene (exons 2 through 9 with intronic sequences) with an attB53 site upstream of the human exon 3 and an frt-flanked neo cassette with a 3' attP50 following the human exon 9. ES cells originally used contained Nr1i2tm1(NR1I2)Arte. Germ line, flp mediated recombination was used to remove the neo cassette. The absence of the endogenous transcript expression was confirmed by qPCR on liver and small intestine extracts. (J:140975)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Nr1i3 Mutation:  27 strains or lines available
References
Original:  J:140975 Scheer N, et al., A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response. J Clin Invest. 2008 Sep;118(9):3228-39
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory