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Transgene Detail
Symbol: Tg(tetO-TGFB1*C223S*C225S)1Glk
Name: transgene insertion 1, Adam Glick
MGI ID: MGI:3815091
Synonyms: tetOTGFB1
Transgene: Tg(tetO-TGFB1*C223S*C225S)1Glk  Location: unknown  
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Inducible, Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsThe porcine TGFbeta1 (TGFB1) cDNA containing a double mutation where cysteines at positions 223 and 225 converted to serines is driven by a heptameric tetO sequence and a CMV minimal promoter. The construct also contains a beta-globin intron. Founders were identified by Southern blotting. Mice express the porcine TGFB1 constitutively as a result of the two mutations. TGFB1 expression can be suppressed by crossing this line with a line expressing the tTA transactivator and maintaining pregnant females on a doxycycline-containing water supply. (J:70670)
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:70670 Liu X, et al., Conditional epidermal expression of TGFbeta 1 blocks neonatal lethality but causes a reversible hyperplasia and alopecia. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9139-44
All:  6 reference(s)

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MGI 6.03
The Jackson Laboratory