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Cxadrtm2Know
Targeted Allele Detail
Nomenclature
Symbol: Cxadrtm2Know
Name: coxsackie virus and adenovirus receptor; targeted mutation 2, Kirk U Knowlton
MGI ID: MGI:3815069
Synonyms: Car
Gene: Cxadr  Location: Chr16:78301496-78359785 bp, + strand  Genetic Position: Chr16, 45.28 cM, cytoband C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140870
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 2, which contains the ATG start codon, was disrupted by the insertion of a beta-Gal/Neo cassette. Gene inactivation was confirmed by immunoblot analysis of embryonic tissue. (J:140870)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cxadr Mutation:  6 strains or lines available
References
Original:  J:140870 Lim BK, et al., Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart. J Clin Invest. 2008 Aug;118(8):2758-70
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory