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Cthtm1Liwu
Targeted Allele Detail
Nomenclature
Symbol: Cthtm1Liwu
Name: cystathionase (cystathionine gamma-lyase); targeted mutation Lingyun Wu
MGI ID: MGI:3814989
Synonyms: Cgl-, CSE-
Gene: Cth  Location: Chr3:157894248-157925077 bp, - strand  Genetic Position: Chr3, 81.55 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140705
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1, 2 and 3 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on liver and kidney extracts. (J:140705)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cth Mutation:  22 strains or lines available
References
Original:  J:140705 Yang G, et al., H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science. 2008 Oct 24;322(5901):587-90
All:  28 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory