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Six3tm3Gco
Targeted Allele Detail
Summary
Symbol: Six3tm3Gco
Name: sine oculis-related homeobox 3; targeted mutation 3, Guillermo Oliver
MGI ID: MGI:3814869
Synonyms: Six3cki, Six3V250
Gene: Six3  Location: Chr17:85921036-85933619 bp, + strand  Genetic Position: Chr17, 55.42 cM
Alliance: Six3tm3Gco page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140315
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA single bp transition (T749C) was introduced into the first exon. This causes a valine to alanine change at amino acid residue 250. In addition, a floxed cassette containing a stop codon and a neomycin resistance gene was inserted upstream of the first exon thus inactivating the knocked-in mutation. (J:140315)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Six3 Mutation:  13 strains or lines available
References
Original:  J:140315 Geng X, et al., Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. Dev Cell. 2008 Aug;15(2):236-47
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory