About   Help   FAQ
Gt(ROSA)26Sortm2(Cd74*)Awai
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm2(Cd74*)Awai
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Ari Waisman
MGI ID: MGI:3814853
Synonyms: Gt(ROSA)26Sortm2Awai, STOPMOG
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140751
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence)
Mutation:    Insertion
 
Gt(ROSA)26Sortm2(Cd74*)Awai expresses 1 gene
 
Mutation detailsA floxed STOP cassette and a Cd74 cDNA in which the sequence encoding the CLIP domain was replaced with the MOG peptide 35-55 were inserted into the locus. Expression of the fusion product is only achieved following cre mediated recombination. (J:140751)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  512 strains or lines available
References
Original:  J:140751 Frommer F, et al., Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion. J Immunol. 2008 Oct 15;181(8):5748-59
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/18/2020
MGI 6.14
The Jackson Laboratory