Gt(ROSA)26Sor^{tm2(Cd74/MOG)Awai}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(Cd74/MOG)Awai}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Ari Waisman
• MGI ID: MGI:3814853
• Synonyms: Gt(ROSA)26Sor^tm2Awai, Gt(ROSA)26Sor^{tm2(Cd74*)Awai}, STOP^MOG
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(Cd74/MOG)Awai} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140751
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2(Cd74/MOG)Awai} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cd74 (MGI:96534)

• Mutation details: A floxed STOP cassette and a Cd74 cDNA in which the sequence encoding the CLIP domain was replaced with the MOG peptide 35-55 were inserted into the locus. Expression of the fusion product is only achieved following cre-mediated recombination. (J:140751)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:140751 Frommer F, et al., Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion. J Immunol. 2008 Oct 15;181(8):5748-59
• All: 1 reference(s)