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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm2(Cd74*)Awai
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Ari Waisman
MGI ID: MGI:3814853
Synonyms: Gt(ROSA)26Sortm2Awai, STOPMOG
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:140751
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence)
Mutation:    Insertion
Gt(ROSA)26Sortm2(Cd74*)Awai expresses 1 gene
Mutation detailsA floxed STOP cassette and a Cd74 cDNA in which the sequence encoding the CLIP domain was replaced with the MOG peptide 35-55 were inserted into the locus. Expression of the fusion product is only achieved following cre mediated recombination. (J:140751)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  512 strains or lines available
Original:  J:140751 Frommer F, et al., Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion. J Immunol. 2008 Oct 15;181(8):5748-59
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory