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Tnk1tm1Sksuf
Targeted Allele Detail
Nomenclature
Symbol: Tnk1tm1Sksuf
Name: tyrosine kinase, non-receptor, 1; targeted mutation 1, W Stratford May
MGI ID: MGI:3814727
Synonyms: Tnk1tm1Wsmay
Gene: Tnk1  Location: Chr11:69741831-69749556 bp, - strand  Genetic Position: Chr11, 42.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140639
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic region including exons 4 - 8 was replaced with a PGK-neo cassette via homologous recombination. Western blot analysis of liver extracts and MEFs confirms the absence of expression of the short isoform. (J:140639)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnk1 Mutation:  24 strains or lines available
References
Original:  J:140639 Hoare S, et al., Tnk1/Kos1 knockout mice develop spontaneous tumors. Cancer Res. 2008 Nov 1;68(21):8723-32
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory