Tc(HSA21)1TybEmcf
Allele Detail

Summary

• Symbol: Tc(HSA21)1TybEmcf
• Name: transchromosomal, human 21, line 1, Victor Tybulewicz and Elizabeth M C Fisher
• MGI ID: MGI:3814712
• Synonyms: Tc1, Tc(HSA21)91-1Emcf
• Gene: Tc(HSA21)1TybEmcf Location: unknown
• Alliance: Tc(HSA21)1TybEmcf page

Mutation origin

• Mutant Cell Line: 91-1
• Germline Transmission: Earliest citation of germline transmission: J:101383
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Not Applicable (Humanized sequence, Inserted expressed sequence)
• Mutation: Other
• Mutation details: A freely segregating chromosome composed of 42 Mb, or 90%, of human chromosome 21 (spanning D21S5-CXADR, D21S1922-IFNAR1 and RUNX1-COL6A1) was created in MPI-VI (129S2/SvPas) ES cells using irradiated microcell-mediated chromosome transfer. (J:101383)

Disease models

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 1 line available
• Carrying any Tc(HSA21)1TybEmcf Mutation: 4 strains or lines available

Notes

ES cell line = MPI-VI.

References

• Original: J:101383 O'Doherty A, et al., An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. Science. 2005 Sep 23;309(5743):2033-7
• All: 29 reference(s)