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Targeted Allele Detail
Symbol: Trpm7tm1Clph
Name: transient receptor potential cation channel, subfamily M, member 7; targeted mutation 1, David E Clapham
MGI ID: MGI:3814705
Synonyms: Trpm7fl
Gene: Trpm7  Location: Chr2:126791565-126876230 bp, - strand  Genetic Position: Chr2, 61.76 cM, cytoband F2
Representative images of grossly deformed, nonviable Trpm7tm1Clph/Trpm7tm1Clph Tg(CAG-cre/Esr1*)5Amc/0 embryos at E9.5 and E10.5

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:140630
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsLoxP sites were inserted around exon 17 and an frt-flanked neo cassette was inserted within the floxed locus. The neo cassette was removed by in vivo flp mediated recombination. (J:140630)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 16 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trpm7 Mutation:  7 strains or lines available
Original:  J:140630 Jin J, et al., Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science. 2008 Oct 31;322(5902):756-60
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory