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Arhgdibtm1Miyo
Targeted Allele Detail
Nomenclature
Symbol: Arhgdibtm1Miyo
Name: Rho, GDP dissociation inhibitor (GDI) beta; targeted mutation 1, Jun Miyoshi
MGI ID: MGI:3814585
Synonyms: RhoGDIbeta, Rho GDIbeta
Gene: Arhgdib  Location: Chr6:136923655-136941899 bp, - strand  Genetic Position: Chr6, 66.72 cM, cytoband G1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140671
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 1.7-kb DNA region covering the promoter region and exons 1 and 2 of the gene locus was replaced by a neomycin resistance cassette. Gene inactivation was confirmed by immunoblot assay on T and B lymphocyte cells collected from the spleen (J:140671)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arhgdib Mutation:  6 strains or lines available
References
Original:  J:140671 Ishizaki H, et al., Defective chemokine-directed lymphocyte migration and development in the absence of Rho guanosine diphosphate-dissociation inhibitors alpha and beta. J Immunol. 2006 Dec 15;177(12):8512-21
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory