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Pkdcctm1Hssk
Targeted Allele Detail
Nomenclature
Symbol: Pkdcctm1Hssk
Name: protein kinase domain containing, cytoplasmic; targeted mutation 1, Hiroshi Sasaki
MGI ID: MGI:3814573
Gene: Pkdcc  Location: Chr17:83215292-83225070 bp, + strand  Genetic Position: Chr17, 52.25 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140470
Parent Cell Line:  TT2F (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1, which contains the transcription start site and the translation initiation sites for both transcripts, and part of intron 1 have been replaced by a neomycin resistance cassette. RT-PCR analysis of total mRNA from whole E9.5 mutant vs. wild type embryos confirmed the absence of transcripts in homozygous mutants. (J:140470)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 16 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pkdcc Mutation:  17 strains or lines available
References
Original:  J:140470 Imuta Y, et al., Short limbs, cleft palate, and delayed formation of flat proliferative chondrocytes in mice with targeted disruption of a putative protein kinase gene, Pkdcc (AW548124). Dev Dyn. 2008 Dec 18;238(1):210-222
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory