Rac1^tm1Atai
Targeted Allele Detail

Summary

• Symbol: Rac1^tm1Atai
• Name: Rac family small GTPase 1; targeted mutation 1, Atsu Aiba
• MGI ID: MGI:3814355
• Synonyms: rac1^flox
• Gene: Rac1 Location: Chr5:143491236-143513786 bp, - strand Genetic Position: Chr5, 82.22 cM
• Alliance: Rac1^tm1Atai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140575
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and an frt flanked neo cassette with a 3' loxP site was inserted downstream of exon 1. Germ line, flp mediated recombination was used to remove the neo cassette leaving exon 1 floxed. (J:140575)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rac1 Mutation: 21 strains or lines available

References

• Original: J:140575 Kassai H, et al., Rac1 in cortical projection neurons is selectively required for midline crossing of commissural axonal formation. Eur J Neurosci. 2008 Jul;28(2):257-67
• All: 12 reference(s)