Trim2^{Gt(IRESBetageo)11Pgr}
Gene trapped Allele Detail

Summary

• Symbol: Trim2^{Gt(IRESBetageo)11Pgr}
• Name: tripartite motif-containing 2; gene trap 11, Peter Gruss
• MGI ID: MGI:3814237
• Synonyms: Trim2^GT
• Gene: Trim2 Location: Chr3:84067746-84214184 bp, - strand Genetic Position: Chr3, 37.48 cM, cytoband F1
• Alliance: Trim2^{Gt(IRESBetageo)11Pgr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140337
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Gene trapped (Hypomorph, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector containing an IRES-beta-geo cassette was inserted into intron 6. Transcript expression was reduced to 5% of wild-type as determined by northern blot analysis. (J:140337)

Expression

In Mice Carrying this Mutation:	35 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim2 Mutation: 38 strains or lines available

References

• Original: J:140337 Balastik M, et al., Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):12016-21
• All: 1 reference(s)