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Gsdmdtm1.1Tshir
Targeted Allele Detail
Summary
Symbol: Gsdmdtm1.1Tshir
Name: gasdermin D; targeted mutation 1.1, Toshihiko Shiroishi
MGI ID: MGI:3814179
Gene: Gsdmd  Location: Chr15:75734176-75739257 bp, + strand  Genetic Position: Chr15, 35.0 cM, cytoband D3-E1
Alliance: Gsdmdtm1.1Tshir page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140319
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination of the Gsdmdtm1Tshir allele removed exons 1 and 2. Gene inactivation was confirmed through northern blotting of total RNA isolated from small intestine. (J:140319)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gsdmd Mutation:  22 strains or lines available
References
Original:  J:140319 Fujii T, et al., Gasdermin D (Gsdmd) is dispensable for mouse intestinal epithelium development. Genesis. 2008 Aug;46(8):418-23
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory