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Vprbptm1.2Yxi
Targeted Allele Detail
Nomenclature
Symbol: Vprbptm1.2Yxi
Name: Vpr (HIV-1) binding protein; targeted mutation 1.2, Yue Xiong
MGI ID: MGI:3814063
Gene: Vprbp  Location: Chr9:106821874-106880992 bp, + strand  Genetic Position: Chr9, 57.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140246
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsLoxP sites were inserted before exon7 and after exon 8 and an Frt flanked neo cassette was inserted upstream of the 5' loxP site via homologous recombination. Cre mediated recombination resulted in deletion of exons 7 and 8. (J:140246)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vprbp Mutation:  42 strains or lines available
References
Original:  J:140246 McCall CM, et al., Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development. Mol Cell Biol. 2008 Sep;28(18):5621-33
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory