About   Help   FAQ
Targeted Allele Detail
Symbol: Dcaf1tm1.2Yxi
Name: DDB1 and CUL4 associated factor 1; targeted mutation 1.2, Yue Xiong
MGI ID: MGI:3814063
Gene: Dcaf1  Location: Chr9:106821874-106880992 bp, + strand  Genetic Position: Chr9, 57.98 cM
Germline Transmission:  Earliest citation of germline transmission: J:140246
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsLoxP sites were inserted before exon7 and after exon 8 and an Frt flanked neo cassette was inserted upstream of the 5' loxP site via homologous recombination. Cre mediated recombination resulted in deletion of exons 7 and 8. (J:140246)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dcaf1 Mutation:  44 strains or lines available
Original:  J:140246 McCall CM, et al., Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development. Mol Cell Biol. 2008 Sep;28(18):5621-33
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory