Tg(DBH-PTS)6Csic
Transgene Detail

Summary

• Symbol: Tg(DBH-PTS)6Csic
• Name: transgene insertion 6, Chiho Sumi-Ichinose
• MGI ID: MGI:3813870
• Synonyms: DPS, DPS-Pts
• Transgene: Tg(DBH-PTS)6Csic Location: unknown
• Alliance: Tg(DBH-PTS)6Csic page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(DBH-PTS)6Csic expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PTS (5805)

  Pts	(MGI:1338783)

• Tg(DBH-PTS)6Csic expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Dbh (MGI:94864)

• Mutation details: This transgene consists of a 5.8 kb fragment containing the 5' promoter region of the human DBH gene, a rabbit beta-globin intron, a Kozak sequence, and a 441 bp cDNA encoding the human PTS gene. Five independent lines were generated. Line 6 was selected for further study. This line carries about 400 copies of the transgene. High levels of PTS activity are detected in the adrenal glands and olfactory bulbs while lower levels are found in other brain regions and the liver. (J:102278)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:102278 Sumi-Ichinose C, et al., Genetically rescued tetrahydrobiopterin-depleted mice survive with hyperphenylalaninemia and region-specific monoaminergic abnormalities. J Neurochem. 2005 Nov;95(3):703-14
• All: 3 reference(s)