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Tg(Ppp1r1b-HTT*)1Meeh
Transgene Detail
Nomenclature
Symbol: Tg(Ppp1r1b-HTT*)1Meeh
Name: transgene insertion 1, Michelle E Erlich
MGI ID: MGI:3813481
Synonyms: D9-N171-98Q, DE5
Transgene: Tg(Ppp1r1b-HTT*)1Meeh  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Ppp1r1b-HTT*)1Meeh expresses 1 gene
 
Mutation detailsA 9 kb genomic fragment containing mouse Ppp1r1b was used to drive expression of an IRES fused cDNA for human HTT that encodes for the first 171 amino acids with an expanded CAG repeat of 98 nucleotides in length in the medium spiny neurons of the striatum. No line information is available. (J:139807)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:139807 Brown TB, et al., Neocortical expression of mutant huntingtin is not required for alterations in striatal gene expression or motor dysfunction in a transgenic mouse. Hum Mol Genet. 2008 Oct 15;17(20):3095-104
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory