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Tg(TcraB12,TcrbB12)1Rest
Transgene Detail
Nomenclature
Symbol: Tg(TcraB12,TcrbB12)1Rest
Name: transgene insertion 1, Nicholas Restifo
MGI ID: MGI:3812191
Synonyms: BgIITG
Transgene: Tg(TcraB12,TcrbB12)1Rest  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(TcraB12,TcrbB12)1Rest expresses 2 genes
 
Mutation detailsRNA was isolated from an I-Ab restricted, Beta-gal specific CD4+ T cell clone. The variable domains for both the Tcra and Tcrb genes were cloned into TCR cassette vectors and co-injected into fertilized embryos. Transgenic mice produce T cells that recognize peptides from the product of the LacZ gene. (J:140121, J:140160)
Phenotypes
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:140121 Ahn S, et al., TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation. PLoS Biol. 2008 Aug 5;6(8):e191
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory