Hsd17b7^tm1Gibo
Targeted Allele Detail

Summary

• Symbol: Hsd17b7^tm1Gibo
• Name: hydroxysteroid (17-beta) dehydrogenase 7; targeted mutation 1, Geula Gibori
• MGI ID: MGI:3811923
• Gene: Hsd17b7 Location: Chr1:169777104-169796810 bp, - strand Genetic Position: Chr1, 76.84 cM
• Alliance: Hsd17b7^tm1Gibo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140055
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the first 4 exons of the locus that encode for the NADH+/catalytic domain of the gene product.. Southern blotting confirmed correct targeting of the locus. (J:140055)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hsd17b7 Mutation: 17 strains or lines available

References

• Original: J:140055 Shehu A, et al., Prolactin receptor-associated protein/17beta-hydroxysteroid dehydrogenase type 7 gene (Hsd17b7) plays a crucial role in embryonic development and fetal survival. Mol Endocrinol. 2008 Oct;22(10):2268-77
• All: 1 reference(s)