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Hsd17b7tm1Gibo
Targeted Allele Detail
Nomenclature
Symbol: Hsd17b7tm1Gibo
Name: hydroxysteroid (17-beta) dehydrogenase 7; targeted mutation 1, Geula Gibori
MGI ID: MGI:3811923
Gene: Hsd17b7  Location: Chr1:169949535-169969241 bp, - strand  Genetic Position: Chr1, 76.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140055
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced the first 4 exons of the locus that encode for the NADH+/catalytic domain of the gene product.. Southern blotting confirmed correct targeting of the locus. (J:140055)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hsd17b7 Mutation:  8 strains or lines available
References
Original:  J:140055 Shehu A, et al., Prolactin receptor-associated protein/17beta-hydroxysteroid dehydrogenase type 7 gene (Hsd17b7) plays a crucial role in embryonic development and fetal survival. Mol Endocrinol. 2008 Oct;22(10):2268-77
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory