Creb3l3^tm1.1Sad
Targeted Allele Detail

Summary

• Symbol: Creb3l3^tm1.1Sad
• Name: cAMP responsive element binding protein 3-like 3; targeted mutation 1.1, Stephen A Duncan
• MGI ID: MGI:3811836
• Synonyms: CrebH^-
• Gene: Creb3l3 Location: Chr10:80920163-80934706 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Creb3l3^tm1.1Sad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140018
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S1/Sv or 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site and a frt-flanked neomycin resistance cassette were inserted between exons 3 and 4, and a second loxP site was inserted between exons 11 and 12. The floxed region included the neo cassette. Mice were crossed with mice carrying Tg(Ella-cre)C5379Lmgd to remove exons 4 through 11 and parts of introns 3 and 11. One loxP site remains downstream of exon 3. Southern blot and PCR analyses on genomic DNA confirmed that the correct targeting and recombination events occurred. (J:140018)

Expression

In Mice Carrying this Mutation:

13 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Creb3l3 Mutation: 20 strains or lines available

Notes

ES cell line = Jxl1.

References

• Original: J:140018 Luebke-Wheeler J, et al., Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H. Hepatology. 2008 Oct;48(4):1242-50
• All: 21 reference(s)