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Targeted Allele Detail
Symbol: Creb3l3tm1.1Sad
Name: cAMP responsive element binding protein 3-like 3; targeted mutation 1.1, Stephen A Duncan
MGI ID: MGI:3811836
Synonyms: CrebH-
Gene: Creb3l3  Location: Chr10:81084324-81098874 bp, - strand  Genetic Position: Chr10, 39.72 cM
Germline Transmission:  Earliest citation of germline transmission: J:140018
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S1/Sv and 129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA loxP site and a frt-flanked neomycin resistance cassette were inserted between exons 3 and 4, and a second loxP site was inserted between exons 11 and 12. The floxed region included the neo cassette. Mice were crossed with mice carrying Tg(Ella-cre)C5379Lmgd to remove exons 4 through 11 and parts of introns 3 and 11. One loxP site remains downstream of exon 3. Southern blot and PCR analyses on genomic DNA confirmed that the correct targeting and recombination events occurred. (J:140018)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Creb3l3 Mutation:  6 strains or lines available
ES cell line = Jxl1.
Original:  J:140018 Luebke-Wheeler J, et al., Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H. Hepatology. 2008 Oct;48(4):1242-50
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.06
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