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Targeted Allele Detail
Symbol: Admtm1.1Mtnz
Name: adrenomedullin; targeted mutation 1.1, Alfredo Martinez
MGI ID: MGI:3811634
Gene: Adm  Location: Chr7:110627661-110629820 bp, + strand  Genetic Position: Chr7, 57.7 cM
Germline Transmission:  Earliest citation of germline transmission: J:138817
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe loxP sites were introduced into both 5' and 3' of 4 exons of the gene from Admtm1Mtnz was deleted by crossing with animals expressing cre under a ubiquitous promoter (unspecified) resulting in a null allele. Homozygous mice showed comlete lack of protein product from conception. (J:138817)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adm Mutation:  9 strains or lines available
Original:  J:138817 Fernandez AP, et al., Lack of adrenomedullin in the mouse brain results in behavioral changes, anxiety, and lower survival under stress conditions. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12581-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory