Slc5a8^tm1.1Boet
Targeted Allele Detail

Summary

• Symbol: Slc5a8^tm1.1Boet
• Name: solute carrier family 5 (iodide transporter), member 8; targeted mutation 1.1, Thomas Boettger
• MGI ID: MGI:3811502
• Gene: Slc5a8 Location: Chr10:88721854-88765377 bp, + strand Genetic Position: Chr10, 44.34 cM
• Alliance: Slc5a8^tm1.1Boet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139883
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 and 5 as well as the neo cassette were removed by germ line, cre mediated recombination. The absence of protein expression was confirmed by immunohistochemistry on colon samples. (J:139883)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc5a8 Mutation: 41 strains or lines available

References

• Original: J:139883 Frank H, et al., Lactaturia and loss of sodium-dependent lactate uptake in the colon of SLC5A8-deficient mice. J Biol Chem. 2008 Sep 5;283(36):24729-37
• All: 7 reference(s)