Pkd1tm3Jzh
Targeted Allele Detail
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Symbol: |
Pkd1tm3Jzh |
Name: |
polycystin 1, transient receptor potential channel interacting; targeted mutation 3, Jing Zhou |
MGI ID: |
MGI:3811233 |
Synonyms: |
Pkd1flox |
Gene: |
Pkd1 Location: Chr17:24768808-24815482 bp, + strand Genetic Position: Chr17, 12.4 cM
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Alliance: |
Pkd1tm3Jzh page
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Germline Transmission: |
Earliest citation of germline transmission:
J:140012
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A loxP-flanked neomycin selection cassette was inserted into the EcoRI site located 1.2 kb upstream of exon 2, and a third loxP site placed downstream of exon 6. Chimeric mice were crossed with Tg(Prm-cre)58Og transgenic mice that express cre recombinase in male germ cells. Offspring were selected that had the neomycin cassette excised, leaving exons 2 through 6 flanked by loxP sites. Correct targeting and excision was confirmed by Southern blotting.
(J:140012)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pkd1 Mutation: |
153 strains or lines available
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Original: |
J:140012 Starremans PG, et al., A mouse model for polycystic kidney disease through a somatic in-frame deletion in the 5' end of Pkd1. Kidney Int. 2008 Jun;73(12):1394-405 |
All: |
14 reference(s) |
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