About   Help   FAQ
Bpnt2Gt(RST634)Byg
Gene trapped Allele Detail
Nomenclature
Symbol: Bpnt2Gt(RST634)Byg
Name: 3'(2'), 5'-bisphosphate nucleotidase 2; gene trap RST634, BayGenomics
MGI ID: MGI:3810994
Synonyms: gPAPPgt
Gene: Bpnt2  Location: Chr4:4762484-4793306 bp, - strand  Genetic Position: Chr4, 2.56 cM
Skeletal abnormalities of Bpnt2Gt(RST634)Byg/Bpnt2Gt(RST634)Byg mutant mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Mutant Cell Line:  RST634
Germline Transmission:  Earliest citation of germline transmission: J:139706
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT0TMpfs     Vector Type: secretory trap
 
Mutation detailsInsertion of the gene-trap vector in the first intron encodes the first exon of Impad1 gene fused to beta-galactosidase. It is predicted to express a truncated mutant protein that would contain only 1 of 13 catalytically conserved residues. Western blot and biochemical analyses confirmed homozygous mice are deficient for functional enzyme. (J:139706)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 28 assay results
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Bpnt2 Mutation:  3 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:139706 Frederick JP, et al., A role for a lithium-inhibited Golgi nucleotidase in skeletal development and sulfation. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11605-12
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/06/2021
MGI 6.16
The Jackson Laboratory