Gpx4^tm2.1Marc
Targeted Allele Detail

Summary

• Symbol: Gpx4^tm2.1Marc
• Name: glutathione peroxidase 4; targeted mutation 2.1
• MGI ID: MGI:3810784
• Gene: Gpx4 Location: Chr10:79883000-79892273 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Gpx4^tm2.1Marc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139668
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Mice carrying the Gpx4^tm2Marc allele were crossed with mice carrying the Tg(Camk2a-cre)2Gsc transgene to remove exons 5-7 from the germline. Deletion of the exons was confirmed by Southern blotting. (J:139668)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpx4 Mutation: 80 strains or lines available

References

• Original: J:139668 Seiler A, et al., Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab. 2008 Sep;8(3):237-48
• All: 1 reference(s)