Gpx4tm2Marc
Targeted Allele Detail
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Symbol: |
Gpx4tm2Marc |
Name: |
glutathione peroxidase 4; targeted mutation 2, Marcus Conrad |
MGI ID: |
MGI:3810783 |
Synonyms: |
Gpx4flox |
Gene: |
Gpx4 Location: Chr10:79883000-79892273 bp, + strand Genetic Position: Chr10, 39.72 cM
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Alliance: |
Gpx4tm2Marc page
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Germline Transmission: |
Earliest citation of germline transmission:
J:139668
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: Exons 5-7 encoding the Sec-insertion sequence element and the polyadenylation signal were flanked by loxP sites. A frt-flanked neomycin resistance cassette was placed immediately downstream of the 3' loxP site. Founder mice were crossed with FLPe deleter mice to remove the neomycin cassette leaving behind a single frt site. Correct targeting was confirmed by Southern blotting.
(J:139668)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gpx4 Mutation: |
80 strains or lines available
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Original: |
J:139668 Seiler A, et al., Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab. 2008 Sep;8(3):237-48 |
All: |
17 reference(s) |
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