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Targeted Allele Detail
Symbol: Del(7Olfr64-Hbb-ar)1Mkg
Name: deletion, Chr 7, Mark Groudine 1
MGI ID: MGI:3810287
Synonyms: deltaHS-62.5-deltaLCR
Gene: Del(7Olfr64-Hbb-ar)1Mkg  Location: unknown  Genetic Position: Chr7, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:139198
Parent Cell Line:  BK4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intergenic deletion
  Del(7Olfr64-Hbb-ar)1Mkg involves 4 genes/genome features (Hbb-ar, Olfr66, Olfr64 ...) View all
Mutation detailsES cells carrying the Hbb-artm1.1Mkg allele, which has most of the Hbb-ar region replaced with a loxP site, were targeted in cis with a construct that replaced the upstream HS-62.5 element with a loxP-flanked neomycin selection cassette. This substitution removed nucleotides -63238 through -59669, relative to the start site of the Hbb-y gene. Transient expression of Cre recombinase eliminated the entire genomic sequence between the newly inserted floxed neo cassette and the loxP site present from the Hbb-artm1.1Mkg allele. This deletion removes genes Olfr64, Olf65, Olf66, and almost all of the Hbb-ar region. (J:139198)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(7Olfr64-Hbb-ar)1Mkg Mutation:  0 strains or lines available
Male ES cells, deltaLCR-D/S-1, were generated from male mice on a 129 background that were heterozygous for the Hbb-artm1.1Mkg allele, carried two different variants of the Hbb genes (HbbD/HbbS) and were hemizygous for the null Hprtb-m3 allele.

Original:  J:139198 Bender MA, et al., Flanking HS-62.5 and 3' HS1, and regions upstream of the LCR, are not required for beta-globin transcription. Blood. 2006 Aug 15;108(4):1395-401
All:  1 reference(s)

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MGI 6.01
The Jackson Laboratory