Kif5c^tm1Gsn
Targeted Allele Detail

Summary

• Symbol: Kif5c^tm1Gsn
• Name: kinesin family member 5C; targeted mutation 1, Lawrence SB Goldstein
• MGI ID: MGI:3809823
• Gene: Kif5c Location: Chr2:49509310-49664790 bp, + strand Genetic Position: Chr2, 28.68 cM, cytoband C
• Alliance: Kif5c^tm1Gsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139716
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2 kb pGK-neo cassette replaces exon 3 of the gene. Full-length protein and mRNA are completely absent in homozygous brain as determined by northern and western blotting, but a truncated 5' mRNA and protein fragment have been detected. (J:139716)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kif5c Mutation: 47 strains or lines available

References

• Original: J:139716 Goldstein LS, Generation of a Kif5C null allele. MGI Direct Data Submission. 2008
• All: 1 reference(s)