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Kif5btm1Njen
Targeted Allele Detail
Nomenclature
Symbol: Kif5btm1Njen
Name: kinesin family member 5B; targeted mutation 1, Nancy A Jenkins
MGI ID: MGI:3809821
Synonyms: Kif5Bfl, Kinesin-1B II
Gene: Kif5b  Location: Chr18:6201005-6241524 bp, - strand  Genetic Position: Chr18, 4.46 cM, cytoband A2-B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:170198
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 2 is flanked by loxP sites. An FRT-flanked neo cassette was removed by flp-mediated recombination. (J:170198)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kif5b Mutation:  40 strains or lines available
References
Original:  J:170198 Cui J, et al., Targeted inactivation of kinesin-1 in pancreatic beta-cells in vivo leads to insulin secretory deficiency. Diabetes. 2011 Jan;60(1):320-30
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory