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Targeted Allele Detail
Symbol: Xiaptm1Hs
Name: X-linked inhibitor of apoptosis; targeted mutation Hermann Steller
MGI ID: MGI:3809790
Synonyms: XIAPdeltaRING
Gene: Xiap  Location: ChrX:42059679-42109656 bp, + strand  Genetic Position: ChrX, 23.19 cM, cytoband A3-A5
Germline Transmission:  Earliest citation of germline transmission: J:138979
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsThe first two codons of the RING doman (C449 and K450) were replaced with STOP codons by homologous recombination. This mutation truncates the RING domain and the 13 amino acid sequence between the RING and C terminus. The frt-flanked neo cassette inserted into intron 2 was removed by germ line, flp mediated recombination. (J:138979)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Xiap Mutation:  33 strains or lines available
Original:  J:138979 Schile AJ, et al., Regulation of apoptosis by XIAP ubiquitin-ligase activity. Genes Dev. 2008 Aug 15;22(16):2256-66
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory