Gapt^tm1.1Wz
Targeted Allele Detail

Summary

• Symbol: Gapt^tm1.1Wz
• Name: Grb2-binding adaptor, transmembrane; targeted mutation 1.1, Weiguo Zhang
• MGI ID: MGI:3809581
• Synonyms: GAPT^-
• Gene: Gapt Location: Chr13:110489150-110493733 bp, - strand Genetic Position: Chr13, 61.87 cM
• Alliance: Gapt^tm1.1Wz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138146
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination was used to remove the coding exon and neo cassette. The absence of protein expression was confirmed by western blot analysis on bone marrow and spleen extracts. (J:138146)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gapt Mutation: 12 strains or lines available

References

• Original: J:138146 Liu Y, et al., Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells. J Leukoc Biol. 2008 Sep;84(3):842-51
• All: 1 reference(s)