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Dicer1tm1.1Snj
Targeted Allele Detail
Nomenclature
Symbol: Dicer1tm1.1Snj
Name: dicer 1, ribonuclease type III; targeted mutation 1.1, Stephen N Jones
MGI ID: MGI:3809262
Synonyms: DicerdeltaC
Gene: Dicer1  Location: Chr12:104687742-104751952 bp, - strand  Genetic Position: Chr12, 54.83 cM, cytoband E-F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:139257
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Cre recombination in ES cells was used to remove exons 15 through 17, which encode the PAZ domain. (J:139257)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dicer1 Mutation:  52 strains or lines available
References
Original:  J:139257 Mudhasani R, et al., Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells. J Cell Biol. 2008 Jun 30;181(7):1055-63
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory