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Tg(Gfap-GFAP*R239H)60TMIke
Transgene Detail
Nomenclature
Symbol: Tg(Gfap-GFAP*R239H)60TMIke
Name: transgene insertion 60TM, Kazuhiro Ikenaka
MGI ID: MGI:3809243
Synonyms: 60TM
Transgene: Tg(Gfap-GFAP*R239H)60TMIke  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Conditional ready, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Gfap-GFAP*R239H)60TMIke expresses 1 gene
 
Mutation detailsThe original construct for this transgene consisted of a 2.5 kb fragment of the mouse Gfap promoter followed by a floxed eGFP cDNA, and a human GFAP alpha isophorm cDNA with the R239H mutation. Line A60 containing more than 10 copies of the construct was repeatedly crossed to a cre deleter strain to remove all of the copies of eGFP. The resulting line (60TM) lacks eGFP but retains an estimated 3 copies of the human GFAP cDNA. Each copy of the human GFAP is preceded by a loxP site allowing for Cre-mediated deletion of all but 1 copy of the human GFAP cDNA. (J:139349)
Phenotypes
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Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:139349 Tanaka KF, et al., Murine model of Alexander disease: analysis of GFAP aggregate formation and its pathological significance. Glia. 2007 Apr 15;55(6):617-31
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory