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G2e3Gt(RRM192)Byg
Gene trapped Allele Detail
Nomenclature
Symbol: G2e3Gt(RRM192)Byg
Name: G2/M-phase specific E3 ubiquitin ligase; gene trap RRM192, BayGenomics
MGI ID: MGI:3808723
Synonyms: G2E3-
Gene: G2e3  Location: Chr12:51395013-51423769 bp, + strand  Genetic Position: Chr12, 22.11 cM
Mutation
origin
Mutant Cell Line:  RRM192
Germline Transmission:  Earliest citation of germline transmission: J:139062
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutations:    Insertion of gene trap vector, Intragenic deletion     Vector: pGT0Lxf     Vector Type: gene trap
 
Mutation detailsThe gene trap vector is inserted in intron 13, about 570 base pairs downstream from the end of exon 13. Insertion also resulted in the deletion of 64 nucleotides from intron 13 just upstream from the insertion site. (J:139062)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 42 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any G2e3 Mutation:  27 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:139062 Brooks WS, et al., G2E3 is a dual function ubiquitin ligase required for early embryonic development. J Biol Chem. 2008 Aug 8;283(32):22304-15
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory