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Targeted Allele Detail
Symbol: Nfasctm1.1Brp
Name: neurofascin; targeted mutation 1.1, Peter J Brophy
MGI ID: MGI:3808598
Gene: Nfasc  Location: Chr1:132564690-132741797 bp, - strand  Genetic Position: Chr1, 57.42 cM
Reduced myelination in the Nfasctm1.1Brp/Nfasctm1.1Brp mouse at P6

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:107591
Parent Cell Line:  E14TG2aIV (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 4 and a floxed neo cassette downstream of exon 4. Transient cre expression in ES cells was used to remove the neo cassette and exon 4. The absence of protein expression was confirmed by western blot analysis on sciatic nerve extracts. (J:107591)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfasc Mutation:  31 strains or lines available
Original:  J:107591 Sherman DL, et al., Neurofascins are required to establish axonal domains for saltatory conduction. Neuron. 2005 Dec 8;48(5):737-42
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
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