Nfasctm1.1Brp
Targeted Allele Detail
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Symbol: |
Nfasctm1.1Brp |
Name: |
neurofascin; targeted mutation 1.1, Peter J Brophy |
MGI ID: |
MGI:3808598 |
Gene: |
Nfasc Location: Chr1:132492428-132669535 bp, - strand Genetic Position: Chr1, 57.42 cM
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Alliance: |
Nfasctm1.1Brp page
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Reduced myelination in the Nfasctm1.1Brp/Nfasctm1.1Brp mouse at P6
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:107591
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Parent Cell Line: |
E14TG2aIV (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site was inserted upstream of exon 4 and a floxed neo cassette downstream of exon 4. Transient cre expression in ES cells was used to remove the neo cassette and exon 4. The absence of protein expression was confirmed by western blot analysis on sciatic nerve extracts.
(J:107591)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Nfasc Mutation: |
61 strains or lines available
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Original: |
J:107591 Sherman DL, et al., Neurofascins are required to establish axonal domains for saltatory conduction. Neuron. 2005 Dec 8;48(5):737-42 |
All: |
10 reference(s) |
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