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Sgpp1tm1(KOMP)Vlcg
Targeted Allele Detail
Nomenclature
Symbol: Sgpp1tm1(KOMP)Vlcg
Name: sphingosine-1-phosphate phosphatase 1; targeted mutation 1, Velocigene
MGI ID: MGI:3808500
Synonyms: Sgpp1tm1Vlcg
Gene: Sgpp1  Location: Chr12:75714249-75735729 bp, - strand  Genetic Position: Chr12, 32.95 cM
Sgpp1tm1(KOMP)Vlcg/Sgpp1tm1(KOMP)Vlcg pups exhibit focal desquamation and abnormal epidermal histology

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Mutant Cell Lines:  10963C-C9, 10963C-E3, 10963C-F1, 10963C-G12
Germline Transmission:  Earliest citation of germline transmission: J:199597
Parent Cell Line:  VGB6 (ES Cell)
Strain of Origin:  C57BL/6NTac
Project Collection: KOMP-Regeneron
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: ZEN-Ub1
 
Mutation detailsThe insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 19624bp between positions 76816924-76836547 of Chromosome 12 (Genome Build37). The lacZ and neomycin resistance cassette replaced the entire coding region from exon 1 to 3. (J:136110, J:199597)
Generation of the Sgpp1tm1(KOMP)Vlcg allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Sgpp1 Mutation:  2 strains or lines available
References
Original:  J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory