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Targeted Allele Detail
Symbol: Hes1tm1Kag
Name: hes family bHLH transcription factor 1; targeted mutation 1, Ryoichiro Kageyama
MGI ID: MGI:3808031
Synonyms: Hes1f, Hes1tm1Imayo
Gene: Hes1  Location: Chr16:29884175-29886614 bp, + strand  Genetic Position: Chr16, 21.09 cM
Germline Transmission:  Earliest citation of germline transmission: J:139170
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted after the first coding exon and a floxed neo cassette was inserted after the last coding exon. Expression of cre in ES cells was used to remove the neo cssette leaving coding exons 2 through 4 floxed. (J:139170)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 28 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Hes1 Mutation:  14 strains or lines available
Original:  J:139170 Imayoshi I, et al., Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline. Development. 2008 Aug;135(15):2531-41
All:  37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory