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Gpsm1tm1.1Lajb
Targeted Allele Detail
Nomenclature
Symbol: Gpsm1tm1.1Lajb
Name: G-protein signalling modulator 1 (AGS3-like, C. elegans); targeted mutation 1.1, Stephen Lanier
MGI ID: MGI:3807518
Synonyms: Gpsm1nullLajb
Gene: Gpsm1  Location: Chr2:26315515-26348237 bp, + strand  Genetic Position: Chr2, 18.73 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:138126
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed and Frted PGK-neo cassette was inserted on one side and a single loxP sites was inserted on the other side of a 410 bp fragment that included exon 3. Cre- and Flp-mediated recombination resulted in removal of exon 3. Immunoblot analysis confirmed the absence of full length protein expression in brains and hearts from homozygous mice. Expression of a short form in the heart is not disrupted in homozygotes. (J:138126)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gpsm1 Mutation:  4 strains or lines available
References
Original:  J:138126 Blumer JB, et al., Activator of G protein signaling 3 null mice: I. Unexpected alterations in metabolic and cardiovascular function. Endocrinology. 2008 Aug;149(8):3842-9
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory