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Pik3cbtm1Jjz
Targeted Allele Detail
Nomenclature
Symbol: Pik3cbtm1Jjz
Name: phosphatidylinositol 3-kinase, catalytic, beta polypeptide; targeted mutation 1, Jean Zhao
MGI ID: MGI:3805847
Synonyms: p110betaflox
Gene: Pik3cb  Location: Chr9:99036654-99140621 bp, - strand  Genetic Position: Chr9, 51.41 cM, cytoband E4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:138565
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn frt-flanked neo cassette with a 5' loxP site was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 2. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 2 floxed. (J:138565)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pik3cb Mutation:  83 strains or lines available
References
Original:  J:138565 Jia S, et al., Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. Nature. 2008 Aug 7;454(7205):776-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory