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Bmi1tm1(cre/ERT)Mrc
Targeted Allele Detail
Nomenclature
Symbol: Bmi1tm1(cre/ERT)Mrc
Name: Bmi1 polycomb ring finger oncogene; targeted mutation 1, Mario R Capecchi
MGI ID: MGI:3805814
Synonyms: Bmi1CreER, Bmi1tm1(cre/ESR1)Mrc
Gene: Bmi1  Location: Chr2:18677018-18686629 bp, + strand  Genetic Position: Chr2, 12.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:138364
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsAn IRES followed by a cre/ERT fusion and an frt-flanked neo cassette was inserted downstream of the translation stop codon. Germ line, flp-mediated recombination was used to remove the neo cassette. (J:138364)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Bmi1     Summary of all recombinase alleles driven by Bmi1. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bmi1 Mutation:  6 strains or lines available
References
Original:  J:138364 Sangiorgi E, et al., Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet. 2008 Jul;40(7):915-20
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory