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Myod1tm1Ahb
Targeted Allele Detail
Summary
Symbol: Myod1tm1Ahb
Name: myogenic differentiation 1; targeted mutation 1, Annick Harel-Bellan
MGI ID: MGI:3804837
Synonyms: MyoDR99,102
Gene: Myod1  Location: Chr7:46025898-46028516 bp, + strand  Genetic Position: Chr7, 30.03 cM
Alliance: Myod1tm1Ahb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:116060
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsLysines 99 and 102 in the first exon were replaced by arginines. In addition, a floxed neo cassette used for selection that had been inserted in between exon 1 and 2, was removed via cre-mediated recombination. This mutation results in a non-acetylatable form of the protein. (J:116060)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myod1 Mutation:  23 strains or lines available
References
Original:  J:116060 Duquet A, et al., Acetylation is important for MyoD function in adult mice. EMBO Rep. 2006 Nov;7(11):1140-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory